Presenilin/ -secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression
نویسندگان
چکیده
منابع مشابه
Presenilin/ -secretase-dependent processing of -amyloid precursor protein regulates EGF receptor expression
Presenilins (PS, PS1/PS2) are necessary for the proteolytic activity of -secretase, which cleaves multiple type I transmembrane proteins including Alzheimer’s -amyloid precursor protein (APP), Notch, ErbB4, etc. Cleavage by PS/ -secretase releases the intracellular domain (ICD) of its substrates. Notch ICD translocates into the nucleus to regulate expression of genes important for development. ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2007
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0703903104